Translational Research

PROFILE

How do our cells sense and respond to internal and external signals? They use very sophisticated networks of molecules known as intracellular signaling pathways. These pathways are not only important for normal cells but also for cells that are at the center of disease conditions. Therefore, the pharmacological modulation of these networks could be a way to develop novel therapies to treat critically ill patients with diseases for which there are limited treatment options. Our lab, which is composed of a unique group of cell biologists, biochemists, pharmacologists and chemists, focuses on the validation and modification of known signaling pathways that can be involved in diseases. Our goal is to bring projects from the bench to the clinic and minimize the time to do so. This approach has been successfully applied to the approval of enzalutamide, a recent drug developed for the treatment of prostate cancer.

LAB MEMBERS

Group Leader: Javier Guerrero, PhD

Research Scientists: Eduardo Riquelme, PhD • Gonzalo Ureta, PhD • Iván Alfaro, PhD • Jennifer Alfaro, PhD • Luz Delgado, PhD(c).

Research Assistants: Luis Gómez • Ainoa Fernandez • Alexandra Córdova • Cledi Cerda • Daniela Quezada • Felipe Pérez de Arce • Glenda Fuentealba • Ingrid Parejas • Javiera De La Cruz • Ma Elizabeth Torres • Ma Jesús Benito • Natalia Valerio • Olivia Farías • Pablo Barra • Patricio Ávila • Simón Carrilo • Felipe Olivares • Katherine Stack • Yasna Venegas • Rodrigo Alarcón.

Technical Assistants: Alfredo Ferrera • Claudia Acuña • Eduardo Beltrán • Odette Ibañez • Erika Vera.

PhD Students: Gonzalo Nuñez • Juan Hormazabal • Sebastián Belmar

SELECTED PUBLICATIONS

  • Cochrane DR, Bernales S, Jacobsen BM, Cittelly DM, Howe EN, D Amato NC, Spoelstra NS, Edgerton SM, Jean A, Guerrero J, Gómez F, Medicherla S, Alfaro IE, McCullagh E, Jedlicka P, Torkko KC, Thor AD, Elias AD, Protter AA, Richer JK. Role of the Androgen Receptor in Breast Cancer and Preclinical Analysis of Enzalutamide. Breast Cancer Res. 16(1):R7. (2014) | PDF | ABSTRACT
  • Guerrero J, Alfaro IE, Gómez F, Protter AA, Bernales S. Enzalutamide, an androgen receptor signaling inhibitor, induces tumor regression in a mouse model of castration-resistant prostate cancer. Prostate. 73(12):1291-305 (2013) | PDF | ABSTRACT
  • Steele J. W., Lachenmayer M. L., Ju S., Stock A., Liken J., Kim S. H., Delgado L. M., Alfaro I. E., Bernales S., Verdile G., Bharadwaj P., Gupta V., Barr R., Friss A., Dolios G., Wang R., Ringe D., Fraser P., Westaway D., George-Hyslop PH. St., Szabo P., Relkin N. R., Buxbaum J. D., Glabe C. G., Protter A. A., Martins R. N., Ehrlich M. E., Petsko G. A., Yue Z., and Gandy S. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol. Psychiatry 1-9 (2012) | PDF | ABSTRACT
  • Steele J. W., Ju S., Lanchenmayer M. L., Liken J., Stock A., Kim S. H., Delgado L. M., Alfaro I. E., Bernales S., Verdile G., Bharadwaj P., Gupta V., Barr R., Friss A., Dolios G., Wang R., Ringe D., Protter A. A., Martins R. N., Ehrlich M. E., Yue Z., Petsko G. A. and Gandy S. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Mol. Psychiatry 1-7 (2012) | PDF | ABSTRACT
  • Giorgetti M., Gibbons J. A., Bernales S., Alfaro I. E., La Rochelle C. D., Cremers T., Altar A., Wronski R., Hutter-Paier B. and Protter A. A. Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with Acetylcholinesterase Inhibition or N-Methyl-d-aspartate receptor antagonism. J. Pharmacol. Exp. Ther. 333 (3): 748–757 | PDF | ABSTRACT
  • Bernales S., Schuck S and Walter P. Selective autophagy of the endoplasmic reticulum. Autophagy 3 (3): 285-287 (2007) | PDF | ABSTRACT
  • Walther T. C., Brickner J. H., Aguilar P. S., Bernales S., Pantoja C. and Walter P. Eisosomes mark static sites of endocytosis. Nature 439, 998-1003 (2006) | PDF | ABSTRACT
  • Bernales S., McDonald K. L. and Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Bio. 4 (12): 2311-2324 (2006) | PDF | ABSTRACT
  • Bernales S., Papa F. R. and Walter P. Intracellular signaling by the unfolded protein response. Annu. Rev. Cell. Dev. Biol. 22, 487–508 (2006) | PDF | ABSTRACT
  • Leber J. H., Bernales S. and Walter P. IRE1-independent gain control of the unfolded protein response. PLoS Biol. 2 (8): 1197-1207 (2004) | PDF | ABSTRACT