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Cluster V

Modeling and Computational Biology

The application of computational modeling techniques has been key to unveil fundamental laws governing complex biological phenomena. This cluster relies on using advanced knowledge from biology, ecology, chemistry, sociology, mathematics and physics to develop computational models to study phenomena occurring at multiple scales. To do so, we combine computational algorithms with massive data available from diverse sources, ranging from public repositories of social data and biological databases to data generated in-house from environmental prospections (metagenomes), laboratory scale microbial cultures, and in vitro experiments.

Research Lines

Complex networks, neuromorphic computing and biophysics of macromolecules

Use of a mixture of molecular modeling and simulation techniques to explore biophysical processes occurring in transmembrane channels.

Evolutionary and functional genomics of extremophiles

Use of massive databases that are publicly available and evolutionary approaches to address the inventory of genes and mechanisms involved in the survival of extremophiles.

Researchers

Raquel Quatrini, PhD

Director of the Microbial Ecophysiology Lab

Principal Investigator

Tomás Pérez-Acle, PhD

Director of the Computational Biology Lab

Principal Investigator

Raul Araya, PhD

Raul Araya, PhD

Associate Researcher

Jose Antonio Garate, PhD

Jose Antonio Garate, PhD

Associate Researcher

Carlos Lagos, PhD

Carlos Lagos, PhD

Associate Researcher

Alberto Martin, PhD

Alberto Martin, PhD

Associate Researcher

Monica Otero, PhD

Monica Otero, PhD

Associate Researcher

Simon Poblete, PhD

Simon Poblete, PhD

Associate Researcher

Latest Publications Cluster V

November 7, 2025

From Transporter to Motor: Evolutionary and Structural Insights 2 into the Emergence of Prestin’s Area-Motor Activity in Mammals
From Transporter to Motor: Evolutionary and Structural Insights 2 into the Emergence of Prestin’s Area-Motor Activity in Mammals

June 20, 2025

Proper pandemic preparedness requires an integrated cross‐regional efort, the case of the ECLIPSE consortium in America: a narrative review
Proper pandemic preparedness requires an integrated cross‐regional efort, the case of the ECLIPSE consortium in America: a narrative review

May 28, 2025

Comparative and systems analyses of Leishmania spp. non-coding RNAs through developmental stages
Comparative and systems analyses of Leishmania spp. non-coding RNAs through developmental stages
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