Research & Development
Promoting discovery through advanced scientific research
Centro Ciencia & Vida is one of Chile’s leading hubs for science, bringing together over 120 researchers united by the goal of expanding knowledge and driving innovation. Their work spans three main fields—Biomedicine, Computational Biology, and Microbiology—which are developed in five collaborative clusters. By organizing research in this way, CCV nurtures both scientific excellence and collaboration at the service of people.
Clusters
The five clusters focus on high-impact diseases (autoimmunity, infections, cancer, and neurodegenerative disorders) and strategic areas such as pandemic preparedness and biomining.
This synergistic structure translates world-class discoveries into technologies and advanced human capital, positioning Chile as a competitive hub for biomedical innovation and talent.
Laboratories
At Centro Ciencia & Vida, laboratory teams investigate biomedicine, microbiology, and computational biology through end-to-end workflows.
Standardized SOPs, quality controls, and technology transfer pipelines ensure reproducible science that translates into diagnostics, therapies, and biotech innovations.
Maria Rosa Bono, PhD
Immunolab at the University of Chile
Enrique Brandan, PhD
Laboratory of Cell Differentiation and Pathology
Alfonso Gonzalez, PhD
Laboratory of Alfonso González
Alvaro Lladser, PhD
Laboratory of Immunoncology
Alejandra Loyola, PhD
Laboratory of Epigenetics and Chromatin
Soledad Matus, PhD
Laboratory of Biology of Neurodegeneration
Rodrigo Pacheco, PhD
Laboratory of Neuroimmunology
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Tomás Pérez-Acle, PhD
Laboratory of Computational Biology
Raquel Quatrini, PhD
Laboratory of Microbial Ecophysiology
Mario Rosemblatt, PhD
Laboratory of Cellular and Molecular Immunology
Cheril Tapia, PhD
Laboratory of Neurobiology of Aging
Nicole Tischler, PhD
Laboratory of Molecular Virology
Publications
Explore peer-reviewed publications across our five research clusters, reflecting international collaboration and translational impact. Indexed outputs have met or exceeded annual targets, and citation rates have risen above projections.
Together, these publications showcase the synergy across clusters and the CCV's progression from foundational discovery to application.
27 de marzo de 2025
IGF2-reprogrammed macrophages ameliorate the inflammatory response and protect against the neuroinflammatory process in Parkinson's disease models
Grunenwald, Felipe; Huerta, Tomas J.; Sepulveda, Denisse; Jerez, Carolina; Urbina, Valentina; Carrera, Barbara; Diaz-Espinoza, Rodrigo; Nova, Esteban; Pacheco, Rodrigo; Martin-Montanez, Elisa; Gil-Rodriguez, Sara; Valverde, Nadia; Garcia-Fernandez, Maria; Aguilera, Carlos; Chana-Cuevas, Pedro; Vidal, Rene L.
6 de mayo de 2025
Renal antigen-presenting cells from ANG II hypertensive donors transfer blood pressure and promote sodium retention
Patricio Araos,; Pablo León; Ignacio Gallegos-Pérez; Carolina Schäfer; Richard García- Betancourt; Edison Salas-Huenuleo; Carolina Prado; Víctor Barrientos; Jessica Liberona; Tomohiro Kojimahara; Stefanny M. Figueroa; Cristián A. Amador; Leandro J. Carreño; Marcelo J. Kogan; Alexis A. Gonzale; Rodrigo Pacheco; Rodrigo Alzamora,; Heddwen L Brooks; Luis Michea
31 de octubre de 2024
The IP3R inhibitor desmethylxestospongin B reduces tumor cell migration, invasion and metastasis by impairing lysosome acidification and β1-integrin recycling
Bustos, Galdo; Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Huerta, Hernan; Puebla, Andrea; Morgado-Caceres, Pablo; Quezada, Camila; Casanova-Canelo, Cesar; Smith-Cortinez, Natalia; Podunavac, Masa; Oyarce, Cesar; Lladser, Alvaro; Farias, Paula; Lovy, Alenka; Molgo, Jordi; Torres, Vicente A.; Zakarian, Armen; Cardenas, J. Cesar
4 de abril de 2025
Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation
de la Pena, Adely; Retamal, Claudio; Perez-Molina, Francisca; Diaz-Valdivia, Nicole; Veloso-Bahamondes, Francisco; Tapia, Diego; Cancino, Jorge; Randow, Felix; Gonzalez, Alfonso; Oyanadel, Claudia; Soza, Andrea
In Numbers
Annual Achivements