Cancer remains a public health problem due to inadequate responses to its onset or later resistance of many different tumors to current therapeutic drugs. This cluster attempts to improve our understanding of recently emerged cellular regulation processes that contribute to cancer progression, unveiling new therapeutic targets and strategies. Based on our results we will study particular aspects of protein trafficking and signaling, cellular plasticity, and genetic and epigenetic regulation in different tumor contexts. We will also study antitumor immunity and immunotherapy strategies, which will help to unveil how tumor cells avoid being recognized as strange immunogenic entities.