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Alejandra Loyola

Principal Investigator

Epigenetics and Chromatin Lab

Dr. Alejandra Loyola studied Biochemistry at Universidad de Chile, completing her thesis on ICAM-1 induction mechanisms in the lab of Drs. María Rosa Bono and Mario Rosemblatt. In 1997, she entered the joint PhD program of Rutgers University and the University of Medicine and Dentistry of New Jersey (USA), where she worked in Dr. Danny Reinberg’s lab on chromatin assembly factors, graduating in 2003.

She then completed postdoctoral training at the Institut Curie (Paris, France) in Dr. Geneviève Almouzni’s lab, studying histone H3 modifications, supported by Institut Curie and EMBO fellowships. In 2006, she continued her research at MD Anderson Cancer Center (Houston, USA) with Dr. Sharon Dent, focusing on histone-modifying enzymes, supported by an Odyssey fellowship.

In 2008, Dr. Loyola returned to Chile and established the Epigenetics and Chromatin Laboratory at Fundación Ciencia & Vida, where she is currently Head of Lab. Her research explores various aspects of chromatin and epigenetics and is funded by national and collaborative grants (including FONDECYT). She has supervised 11 professional degree theses, 6 master’s theses, and 9 PhD theses, and has hosted five postdoctoral researchers. Dr. Loyola is recognized as a leader in chromatin biology in Chile.

Collaborations

Genevieve Almouzni | Institut Curie Thelma Escobar | Washington University Axel Imhof, LMU | Ludwig-Maximilians-Universität, Munich University Danny Reinberg | University of Miami

Grants

FONDECYT R-1240409 [2024-2028]: The role of methylation and ADP-ribosylation on newly synthesized histones H3 and H4. (Principal Investigator) FB210008 [2021-2031]: Proyecto Financiamiento Basal de Centros de Excelencia, Centro Ciencia & Vida (Principal Investigator). FONDECYT R-1200577 [2022-2024]: Processing of newly synthesized histones H3 and H4 influences chromatin structure. (Principal Investigator)

Featured Publications presents a curated selection of the researcher’s most significant scientific contributions, reflecting their expertise, findings, and the broader impact of their work in advancing knowledge within their field.

Selected Publications

Scientific Reports
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Biochimical Journal
Histone supply: a precious commodity for cell identity
Histone supply: a precious commodity for cell identity
International Journal of Molecular Sciences
The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
International Journal of Molecular Sciences
Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas
Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas

Scientific Reports

Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging

Jesús Llanquinao-Sandoval, Karina A. Cicali, Claudia Jara, Carlos Vigil-Vásquez, Marcela K. Sjöberg-Herrera, Micaela Ricca, Sebastian Valenzuela, Alejandra Loyola, Marcello Pinti, Andreas Schüller, Bredford Kerr & Cheril Tapia-Rojas

Biochimical Journal

Histone supply: a precious commodity for cell identity
Histone supply: a precious commodity for cell identity

Sara Gonske ; Thelma M. Escobar; Alejandra Loyola

International Journal of Molecular Sciences

The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer

Villanueva, R.A.; Loyola, A.

International Journal of Molecular Sciences

Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas
Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas

Cruz P, Peña-Lopez D, Figueroa D, Riobo I, Benedetti V, Saavedra F, Espinoza-Arratia C, Escobar T, Lladser A, Loyola A.

Scientific Reports

Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
https://www.nature.com/articles/s41598-025-24766-2
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Jesús Llanquinao-Sandoval, Karina A. Cicali, Claudia Jara, Carlos Vigil-Vásquez, Marcela K. Sjöberg-Herrera, Micaela Ricca, Sebastian Valenzuela, Alejandra Loyola, Marcello Pinti, Andreas Schüller, Bredford Kerr & Cheril Tapia-Rojas

Biochimical Journal

Histone supply: a precious commodity for cell identity
https://doi.org/10.1042/BCJ20253163
Histone supply: a precious commodity for cell identity
Sara Gonske ; Thelma M. Escobar; Alejandra Loyola

International Journal of Molecular Sciences

The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
https://doi.org/10.3390/ijms26083552
The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
Villanueva, R.A.; Loyola, A.

International Journal of Molecular Sciences

Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas
https://doi.org/10.3390/ijms251910689
Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas
Cruz P, Peña-Lopez D, Figueroa D, Riobo I, Benedetti V, Saavedra F, Espinoza-Arratia C, Escobar T, Lladser A, Loyola A.
Scientific Reports
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Biochimical Journal
Histone supply: a precious commodity for cell identity
Histone supply: a precious commodity for cell identity
International Journal of Molecular Sciences
The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
The Intrinsically Disordered Region of HBx and Virus–Host Interactions: Uncovering New Therapeutic Approaches for HBV and Cancer
International Journal of Molecular Sciences
Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas
Unraveling the Role of JMJD1B in Genome Stability and the Malignancy of Melanomas
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