Alvaro Lladser, PhD

Principal Investigator

Immunoncology Lab

Dr. Lladser is a Biochemist with a PhD in Biomedical Sciences from Universidad de Chile, and did his postdoctoral training at the Cancer Center of the Karolinska Institute, Stockholm, Sweden.

Since the end of 2010, Dr. Lladser directs the Laboratory of Immunoncology at Fundación Ciencia & Vida and since 2019 he is Associate Professor at the Faculty of Medicine and Science of Universidad San Sebastián. He is currently Principal Investigator of the Centro Basal Ciencia & Vida (FB210008), of a FONDECYT Regular grant (1212070), and coinvestigator in several collaborative projects.

His research focuses on unraveling the complex molecular and cellular networks that underlie effective T cell-mediated antitumor immunity by analyzing human samples using high-dimensional transcriptomics and phenotypic analyses, as well as ex vivo functional assays and in vivo tumor models.

Grants

2031-2021Principal Investigator Centro Basal Centro Ciencia & Vida, FB210008. ANID, Chile. 2030-2025Principal Investigator FONDECYT Regular Grant 1251312. ANID, Chile. Unveiling the helper role of Treg cells in long-lasting CD8 T cell immunity induced by cancer immunotherapy. Since 2025 Principal Investigator, Collaboration Fundación Ciencia & Vida - Fundación López Pérez. 2025-2024 Principal Investigator PCI-FOVI240247: Red de Colaboración en Inmunología e Inmunoterapia entre Francia, Argentina y Chile. 2025-2022Co-Investigator FONDEF IDeA Grant ID22I1007. PI: Dr. Rodrigo Pacheco. ANID, Chile. Evaluación de la eficacia y seguridad de una inmunoterapia supresora específica para alfa-sinucleina nitrada como tratamiento para la enfermedad de Parkinson en un modelo preclínico. 2026-2022Co-Investigator FONDECYT Regular Grant 1220196. PI: Dr. Daniela Sauma, ANID, Chile. Not too much, not too little, just right: the unexpected role of adenosine in the antitumor immune response. 2025-2021Principal Investigator FONDECYT Regular Grant 1212070. ANID, Chile. Unveiling the crosstalk between CD8 T cells and dendritic cells underlying effective and long-lasting antitumor immunity.

Collaborations

Dr. Maria Rosa Bono, Dr. Daniela Sauma. Dr. Fabiola Osorno, Dr. Flavio Salazar | Universidad de Chile Dr. Eliane Piaggio, Dr. Ana María Lennon | Institut Curie Dr. Felipe Galvez-Cancino | University of Oxford Dr. Sergio Quezada | University College London Dr. Eduardo Villablanca | Karolinska Institutet Dr. Manuel Varas Godoy, Dr. Rodrigo Pacheco, Dr. Alejandra Loyola, Dr. Hugo González, Dr. Alberto Martín | Universidad San Sebastián

Selected Publications

Featured Publications presents a curated selection of the researcher’s most significant scientific contributions, reflecting their expertise, findings, and the broader impact of their work in advancing knowledge within their field.

Oncoimmunology

DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 + T cell responses and therapeutic protection in mouse tumor models

https://doi.org/10.1080/2162402X.2025.2606497

Bioinformatics Advances

scExplorer: a comprehensive web server for single-cell RNA sequencing data analysis

https://doi.org/10.1093/bioadv/vbaf273

Cell

Exploring Latin America one cell at a time

https://doi.org/10.1016/j.cell.2025.09.013

Immunity

Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies

https://doi.org/10.1016/j.immuni.2025.05.019