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Cluster I

Immune Intervention and Inflammation

At present, there is no clear evidence of the origin and conditions leading to autoimmune diseases. The main focus of this cluster is on the immune response, with an ultimate view on how its manipulation under several conditions could bring about therapeutic approaches. We will join forces to deepen our understanding of the immune processes leading to autoimmune disorders in Parkinson’s disease, lupus, and multiple sclerosis (MS).

Research Lines

Mechanism of autoimmunity

Studies to deepen our understanding of the immune processes that lead to autoimmune disorders.

Epigenetics and autoimmunity

Studies on the mechanism of how the stability of lymphocytes is controlled by epigenetic changes in promoter genes encoding master transcription factors.

Researchers

Rodrigo Pacheco, PhD

Rodrigo Pacheco, PhD

Director of the Neuroimmunology Lab

Principal Investigator

Alvaro Lladser, PhD

Alvaro Lladser, PhD

Director of the Immunoncology Lab

Principal Investigator

Maria Rosa Bono, PhD

Maria Rosa Bono, PhD

Director at Immunology Lab at the Universidad de Chile

Principal Investigator

Mario Rosemblatt, PhD

Mario Rosemblatt, PhD

Director of the Cellular and Molecular Immunology Lab

Principal Investigator

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Carolina Prado, PhD

Associate Researcher

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Sarah Nuñez, PhD

Associate Researcher

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Fabiola Osorio, PhD

Associate Researcher

Latest Publications Cluster I

December 30, 2025

Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice
Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice

October 16, 2025

The Heteromeric Dopamine Receptor D2:D3 Controls the Gut Recruitment and Suppressive Activity of Regulatory T-Cells
The Heteromeric Dopamine Receptor D2:D3 Controls the Gut Recruitment and Suppressive Activity of Regulatory T-Cells

October 16, 2025

Immunoregulatory functions of the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 in myeloid cell biology
Immunoregulatory functions of the endoplasmic reticulum stress sensor inositol-requiring enzyme 1 in myeloid cell biology
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