Alvaro Lladser
Principal Investigator
Immunoncology Lab
Dr. Lladser is a Biochemist with a PhD in Biomedical Sciences from Universidad de Chile, and did his postdoctoral training at the Cancer Center of the Karolinska Institute, Stockholm, Sweden.
Since the end of 2010, Dr. Lladser directs the Laboratory of Immunoncology at Fundación Ciencia & Vida and since 2019 he is Associate Professor at the Faculty of Medicine and Science of Universidad San Sebastián. He is currently Principal Investigator of the Centro Basal Ciencia & Vida (FB210008), of a FONDECYT Regular grant (1212070), and coinvestigator in several collaborative projects.
His research focuses on unraveling the complex molecular and cellular networks that underlie effective T cell-mediated antitumor immunity by analyzing human samples using high-dimensional transcriptomics and phenotypic analyses, as well as ex vivo functional assays and in vivo tumor models.
Grants
Collaborations
Selected Publications
Oncoimmunology
DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 + T cell responses and therapeutic protection in mouse tumor models
Morgado-Cáceres P, Hofmann-Vega F, Figueroa D, Saavedra-Almarza J, Gálvez-Cancino F, Díaz X, Menares E, Roa E, Hidalgo S, Varas-Godoy M, Borgna V, Lladser A
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Morgado-Cáceres P, Hofmann-Vega F, Figueroa D, Saavedra-Almarza J, Gálvez-Cancino F, Díaz X, Menares E, Roa E, Hidalgo S, Varas-Godoy M, Borgna V, Lladser A
Bioinformatics Advances
scExplorer: a comprehensive web server for single-cell RNA sequencing data analysis
Hernández-Galaz S, Hernández-Olivera A, Villanelo F, Lladser A, Martin AJM
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Hernández-Galaz S, Hernández-Olivera A, Villanelo F, Lladser A, Martin AJM
Cell
Exploring Latin America one cell at a time
Possik PA, Adams DJ, Aguiar FC, Alves TC, Alves-Hanna FS, Restrepo Arboleda CM, Armingol E, Arruda LB, Astroz YC, Boccacino JM, Bonfim DC, Calderon JF, Murillo Carrasco AG, Carvalho DG, Carvalho BS, Sanches Daltro de Carvalho PV, Castro A, Chappell L, Chinchilla-Monge R, Di Bella D, Gomes Dias SM, Fagundes R, Fernández ML, Frade BB, Garde FJ, Gonzalez H, Guimarães GR, Inchausti L, Kordon E, Leaden L, Lima RS, Lladser A, López-Castiblanco J, Malta I, Maracaja-Coutinho V, Marchese D, Matimba A, Moreno-Estrada A, Mori MA, Nakaya H, Pereyra S, Romo Ramos YJ, Rego N, Robles-Espinoza CD, Rojas-Hidalgo A, Rubinsztain MN, Santos L, Scoones A, Severino P, Sousa-Squiavinato ACM, Spangenberg L, Suescún AV, Tessarollo NG, Vázquez-Cruz ME, Zawati MH, Viola JPB, Boroni M
Possik PA, Adams DJ, Aguiar FC, Alves TC, Alves-Hanna FS, Restrepo Arboleda CM, Armingol E, Arruda LB, Astroz YC, Boccacino JM, Bonfim DC, Calderon JF, Murillo Carrasco AG, Carvalho DG, Carvalho BS, Sanches Daltro de Carvalho PV, Castro A, Chappell L, Chinchilla-Monge R, Di Bella D, Gomes Dias SM, Fagundes R, Fernández ML, Frade BB, Garde FJ, Gonzalez H, Guimarães GR, Inchausti L, Kordon E, Leaden L, Lima RS, Lladser A, López-Castiblanco J, Malta I, Maracaja-Coutinho V, Marchese D, Matimba A, Moreno-Estrada A, Mori MA, Nakaya H, Pereyra S, Romo Ramos YJ, Rego N, Robles-Espinoza CD, Rojas-Hidalgo A, Rubinsztain MN, Santos L, Scoones A, Severino P, Sousa-Squiavinato ACM, Spangenberg L, Suescún AV, Tessarollo NG, Vázquez-Cruz ME, Zawati MH, Viola JPB, Boroni M
Immunity
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies
Felipe Galvez-Cancino, Mariela Navarrete, Gordon Beattie, Simone Puccio, Enrique Conde-Gallastegi, Kane Foster, Yasmin Morris, Teerapon Sahwangarrom, Despoina Karagianni, Jiali Liu, Alvin J X Lee, Dimitrios A Garyfallos, Alexander P Simpson, Gerasimos-Theodoros Mastrokalos, Francesco Nannini, Cristobal Costoya, Varshaa Anantharam, Beatrice Claudia Cianciotti, Leanne Bradley, Claudia Garcia-Diaz, Melanie Clements, Aditya Shroff, Fatemeh Vahid Dastjerdi, Enrique Miranda Rota, Shahida Sheraz, Robert Bentham, Imran Uddin, Henning Walczak, Alvaro Lladser, James L Reading, Kerry A Chester, Martin A Pule, Paul M Brennan, Samuel Marguerat, Simona Parrinello, Karl S Peggs, Nicholas McGranahan, Enrico Lugli, Kevin Litchfield, Steven M Pollard, Sergio A Quezada
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Felipe Galvez-Cancino, Mariela Navarrete, Gordon Beattie, Simone Puccio, Enrique Conde-Gallastegi, Kane Foster, Yasmin Morris, Teerapon Sahwangarrom, Despoina Karagianni, Jiali Liu, Alvin J X Lee, Dimitrios A Garyfallos, Alexander P Simpson, Gerasimos-Theodoros Mastrokalos, Francesco Nannini, Cristobal Costoya, Varshaa Anantharam, Beatrice Claudia Cianciotti, Leanne Bradley, Claudia Garcia-Diaz, Melanie Clements, Aditya Shroff, Fatemeh Vahid Dastjerdi, Enrique Miranda Rota, Shahida Sheraz, Robert Bentham, Imran Uddin, Henning Walczak, Alvaro Lladser, James L Reading, Kerry A Chester, Martin A Pule, Paul M Brennan, Samuel Marguerat, Simona Parrinello, Karl S Peggs, Nicholas McGranahan, Enrico Lugli, Kevin Litchfield, Steven M Pollard, Sergio A Quezada
Selected Publications
Oncoimmunology
DNA prime and peptide boost immunization elicits robust neoantigen-specific CD8 + T cell responses and therapeutic protection in mouse tumor models
Morgado-Cáceres P, Hofmann-Vega F, Figueroa D, Saavedra-Almarza J, Gálvez-Cancino F, Díaz X, Menares E, Roa E, Hidalgo S, Varas-Godoy M, Borgna V, Lladser A
Bioinformatics Advances
scExplorer: a comprehensive web server for single-cell RNA sequencing data analysis
Hernández-Galaz S, Hernández-Olivera A, Villanelo F, Lladser A, Martin AJM
Cell
Exploring Latin America one cell at a time
Possik PA, Adams DJ, Aguiar FC, Alves TC, Alves-Hanna FS, Restrepo Arboleda CM, Armingol E, Arruda LB, Astroz YC, Boccacino JM, Bonfim DC, Calderon JF, Murillo Carrasco AG, Carvalho DG, Carvalho BS, Sanches Daltro de Carvalho PV, Castro A, Chappell L, Chinchilla-Monge R, Di Bella D, Gomes Dias SM, Fagundes R, Fernández ML, Frade BB, Garde FJ, Gonzalez H, Guimarães GR, Inchausti L, Kordon E, Leaden L, Lima RS, Lladser A, López-Castiblanco J, Malta I, Maracaja-Coutinho V, Marchese D, Matimba A, Moreno-Estrada A, Mori MA, Nakaya H, Pereyra S, Romo Ramos YJ, Rego N, Robles-Espinoza CD, Rojas-Hidalgo A, Rubinsztain MN, Santos L, Scoones A, Severino P, Sousa-Squiavinato ACM, Spangenberg L, Suescún AV, Tessarollo NG, Vázquez-Cruz ME, Zawati MH, Viola JPB, Boroni M
Immunity
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies
Felipe Galvez-Cancino, Mariela Navarrete, Gordon Beattie, Simone Puccio, Enrique Conde-Gallastegi, Kane Foster, Yasmin Morris, Teerapon Sahwangarrom, Despoina Karagianni, Jiali Liu, Alvin J X Lee, Dimitrios A Garyfallos, Alexander P Simpson, Gerasimos-Theodoros Mastrokalos, Francesco Nannini, Cristobal Costoya, Varshaa Anantharam, Beatrice Claudia Cianciotti, Leanne Bradley, Claudia Garcia-Diaz, Melanie Clements, Aditya Shroff, Fatemeh Vahid Dastjerdi, Enrique Miranda Rota, Shahida Sheraz, Robert Bentham, Imran Uddin, Henning Walczak, Alvaro Lladser, James L Reading, Kerry A Chester, Martin A Pule, Paul M Brennan, Samuel Marguerat, Simona Parrinello, Karl S Peggs, Nicholas McGranahan, Enrico Lugli, Kevin Litchfield, Steven M Pollard, Sergio A Quezada