One of the main topics our laboratory focuses on is the breakdown of immune tolerance, a phenomenon that underlies the development of autoimmune diseases. These conditions arise when the immune system mistakenly targets the body’s own tissues, leading to chronic inflammation and organ damage. We investigate how the trafficking and localization of antigen-presenting cells, such as dendritic cells and B lymphocytes, contribute to the initiation and progression of autoimmunity. Our goal is to identify key mechanisms that disrupt immune balance, considering the influence of genetic, hormonal, and environmental factors.

In parallel, we study the complex relationship between the immune system and cancer, with special emphasis on the role of cytotoxic CD8+ T cells in tumor control. Despite their presence, tumor growth often persists due to immunosuppressive signals in the microenvironment, including adenosine, which promotes T cell exhaustion. Our work highlights the importance of TPEX cells, a stem-like subset of exhausted CD8+ T cells defined by TCF1 expression, that respond favorably to PD1 therapy. We are exploring how adenosine, produced by CD73, shapes the differentiation and maintenance of TPEX cells, balancing its immunosuppressive effects with its capacity to sustain long-term antitumor immunity. Through this research, we aim to acquire a better understanding of the mechanisms that determine effective immune responses and improve strategies for the treatment of both autoimmune diseases and cancer.