Cheril Tapia
Principal Investigator
Neurobiology of Aging Lab
Dr. Cheril Cecilia Tapia Rojas is a biochemist who earned her BSc and a PhD in Cellular and Molecular Biology from Pontificia Universidad Católica de Chile. After completing postdoctoral research funded by the ANILLO ACT1411 grant (Chile) at Universidad Autónoma de Chile, she joined Universidad San Sebastián in 2018 as Assistant Professor sponsored by the program that subsidizes installation in academia (PAI77170091), and secured a FONDECYT Initiation grant that same year.
She leads the Neurobiology of Aging Laboratory (NBA‑Lab) at the Centro Basal Ciencia & Vida. Her research focuses on synaptic mitochondrial dysfunction in the aging hippocampus, investigating how factors such as phosphorylated tau and reduced Lonp1 protease activity contribute to memory decline and impaired neuroenergetics. Her team employs mouse primary neuron cultures, organotypic slices, and aged mouse models (strains C57BL6 and SAMP8) to explore these mechanisms.
Dr. Tapia Rojas is actively involved in teaching and mentorship across undergraduate Biochemistry programs and graduate studies, including the PhD in Cell Biology and Biomedicine program and the PhD in Biotechnology and Bioentrepreneurship program at USS. She has more than 55 research publications and multiple funded projects, including FONDECYT grants, and she is recognized nationally and internationally for her contributions to understanding aging and mitochondrial biology.
Collaborations
Grants
Featured Publications presents a curated selection of the researcher’s most significant scientific contributions, reflecting their expertise, findings, and the broader impact of their work in advancing knowledge within their field.
Selected Publications
NPJ Aging
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment
Cell Death & Disease
Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice
Scientific Reports
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
Neural Regeneration Research
Synaptic mitochondria in aging and neurodegenerative diseases: unraveling their functional decline and vulnerability
NPJ Aging
Early mitophagy activation by Urolithin A prevents, but late activation does not reverse, age-related cognitive impairment

Claudia Jara, Leslye Venegas-Zamora, Han S. Park-Kang, Matías Lira, Micaela Ricca, Sebastian Valenzuela & Cheril Tapia-Rojas
Cell Death & Disease
Unraveling sex differences in age-related hippocampal decline: differential mitochondrial dysfunction, Lonp1-dependent mitochondrial proteostasis and mtROS production in aged C57BL/6 mice
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Karina A. Cicali, Claudia Jara, Daniela Cortés-Díaz, Matías Lira, Ítalo Fuentes, Alejandra Catenaccio Josefa Arnaíz, Micaela Ricca, Sebastián Valenzuela, Carolina A. Oliva, Daniela S. Rivera and Cheril Tapia-Rojas
Scientific Reports
Identifying a novel Mecp2-mediated epigenetic mechanism controlling Lonp1 in the hippocampus and its disruption by aging
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Jesús Llanquinao-Sandoval, Karina A. Cicali, Claudia Jara, CarlosVigil-Vásquez,
Marcela K. Sjöberg-Herrera, Micaela Ricca, SebastianValenzuela, Alejandra Loyola,
Marcello Pinti, Andreas Schüller, Bredford Kerr& CherilTapia-Rojas
Neural Regeneration Research
Synaptic mitochondria in aging and neurodegenerative diseases: unraveling their functional decline and vulnerability
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Karina A. Cicali, Angie K. Torres, Cheril Tapia-Rojas1
NPJ Aging

Cell Death & Disease
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Scientific Reports
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Neural Regeneration Research
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