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Enrique Brandan, PhD

Principal Investigator

Cell Differentiation and Pathology Lab

Dr. Enrique Brandan earned his degree in Biology from Universidad de Chile in 1978 and a PhD in Cell Biology from Pontificia Universidad Católica de Chile in 1985. He conducted postdoctoral training in the United States at Saint Louis University and the University of Massachusetts.

In 1988, he joined the Faculty of Biological Sciences at Pontificia Universidad Católica de Chile, where he became Full Professor in 1999. Since 2019, he has been part of Fundación Ciencia & Vida.

Dr. Brandan is a member of the Chilean Academy of Sciences (2007) and the Latin American Academy of Sciences (2017). He was an International Research Scholar of the Howard Hughes Medical Institute (1997–2006) and received the Chilean Presidential Chair in Sciences (1998–2001). His research has been supported by international and national institutions, including MDA, HHMI, NSF, Fogarty International, TWAS, Volkswagen-Stiftung, IFS, and ANID (formerly CONICYT).

He served as President of the Chilean Society for Cell Biology and held leadership roles at Pontificia Universidad Católica de Chile, including Chair of the Cellular and Molecular Biology Department. Students have recognized his teaching by naming him "Best Teacher" twice, and he has mentored more than 40 graduate and undergraduate students.

Grants

FONDEF-ID25I10016 [2025-2027]: Novedosa aproximación para el tratamiento contra la fibrosis: desarrollo y evaluación de nuevos péptidos inhibidores del factor de crecimiento pro-fibrótico de tejido conectivo (CTGF). (Principal Investigator) FONDECYT R-1190144 [2022-2023]: Role of the lpa/lpars axis in skeletal muscle fibrosis. (Principal Investigator)

Collaborations

Jerold Chun | Center of Neurologic Diseases (https://sbpdiscovery.org/scientists/jerold-chun-md-phd/)

Selected Publications

Featured Publications presents a curated selection of the researcher’s most significant scientific contributions, reflecting their expertise, findings, and the broader impact of their work in advancing knowledge within their field.

JCI Insight
Lysophosphatidic acid mediates skeletal muscle fibrosis in denervation via activation of YAP/TAZ
Skeletal Muscle
Dysregulated ATX-LPA and YAP/TAZ signaling in dystrophic Sgcd−/− mice with early fibrosis and inflammation
Matrix Biology
Involvement of lysophosphatidic acid-LPA1-YAP signaling in healthy and pathological FAPs migration
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