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Rodrigo Pacheco, PhD

Principal Investigator

Neuroimmunology Lab

Dr. Rodrigo Pacheco earned his Biochemistry degree from Pontificia Universidad Católica de Chile in 2001, receiving top honors in his class. His thesis focused on the mechanism of action of urushiol allergens. He later pursued a PhD in Molecular Neurobiology at Universitat de Barcelona, where he studied how glutamate and adenosine deaminases modulate human dendritic cells and CD4+ T-cell function. His thesis was recognized as high-impact research by the university, and he earned his doctorate in 2006.

Upon returning to Chile, Dr. Pacheco completed postdoctoral training at Pontificia Universidad Católica de Chile, investigating the role of Fc-gamma receptors in dendritic cells, particularly in autoimmune and infectious disease contexts.

In 2008, he established the Laboratory of Neuroimmunology at Fundación Ciencia & Vida. His research focuses on understanding how dopamine regulates neuro-immune interactions. His team explores the role of dopamine in autoimmune diseases, cancer, neurodegenerative disorders, and behavior, aiming to reveal novel therapeutic pathways. Through his interdisciplinary approach, Dr. Pacheco has become a key figure in advancing neuroimmunology in Chile.

Grants

FONDECYT R-1250021 [2025-2029] : Deciphering the role of the short-chain fatty acids receptor GPR43 in the interplay between T-cells and the microbiota in the development of motor and non-motor manifestations in Parkinson's disease. (Principal Investigator) FONDECYT R-1231909 [2024-2026]: EVALUATING THE PRO-INFLAMMATORY ROLE OF NGAL RECEPTOR IN THE PROGRESSION OF PROTEINURIC CHRONIC KIDNEY DISEASE. (Coinvestigator)

Collaborations

Sergio Quezada; University College London Fabiola Osorio; Universidad de Chile Jimmy Stehberg; Universidad Andrés Bello Felipe Court; Universidad Mayor Erick Riquelme; Pontificia Universidad Católica de Chile Rodrigo Naves; Universidad de Chile Luis Michea; Universidad de Chile Cristián Amador; Universidad San Sebastián Eugenia Morselli; Universidad San Sebastián Jaime Gutiérrez; Universidad San Sebastián

Selected Publications

Featured Publications presents a curated selection of the researcher’s most significant scientific contributions, reflecting their expertise, findings, and the broader impact of their work in advancing knowledge within their field.

International Journal of Molecular Sciences
The heteromeric dopamine receptor D2:D3 controls the gut recruitment and suppressive activity of regulatory T cells
Brain
The immune system in Parkinson’s disease: what we know so far
Pharmacological Reviews
Regulation of pain perception by microbiota in Parkinson’s Disease
Journal of Neuroinflammation
GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity
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