Soledad Matus
Principal Investigator
Biology of Neurodegeneration Lab
Dr. Matus is a biochemist and earned her PhD degree in 2007 at the Faculty of Medicine, Pontificia Universidad Católica de Chile, in Santiago, Chile.
During her PhD studies conducted at the laboratory of Dr. Alfonso González, she worked on a biomedical project in the field of neurobiology aiming to understand the connection between autoimmunity and neurological disorders in the context of human pathology.
She performed postdoctoral training (2008-2011) in protein misfolding and amyotrophic lateral sclerosis (ALS) at the laboratory of Dr. Claudio Hetz at Universidad de Chile supported by a fellowship from the ALS Association (USA). Dr. Matus then started her own laboratory at Neurounion Biomedical Foundation. In 2017 she began her work as principal investigator of the Laboratory of Biology of Neurodegeneration at Fundación Ciencia & Vida.
Grants
Collaborations
Selected Publications
Neurobiology of Disease
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
Nicolás W. Martínez, Felipe Gómez, Ariel Tapia-Godoy, Juan Francisco Roa, Fernanda Moreso-Contreras, Yuwei Liu, Claudia Jara, Cheril Tapia-Rojas, Iván Alfaro, Mauro Costa-Mattioli, Soledad Matus
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Nicolás W. Martínez, Felipe Gómez, Ariel Tapia-Godoy, Juan Francisco Roa, Fernanda Moreso-Contreras, Yuwei Liu, Claudia Jara, Cheril Tapia-Rojas, Iván Alfaro, Mauro Costa-Mattioli, Soledad Matus
PLOS One
Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology
Vegas-Gomez L, Pizarro M, Garcia-Martin J, Arredondo-Alcala MA, Bustamante B, Gonzalez-Silva C, et al.
Vegas-Gomez L, Pizarro M, Garcia-Martin J, Arredondo-Alcala MA, Bustamante B, Gonzalez-Silva C, et al.
Journal of autoimmunity
Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease
Isabel Castro, Patricia Carvajal, Sergio Aguilera, María-José Barrera, Soledad Matus, Sergio González, Claudio Molina, María-Julieta González
Isabel Castro, Patricia Carvajal, Sergio Aguilera, María-José Barrera, Soledad Matus, Sergio González, Claudio Molina, María-Julieta González
Selected Publications
Neurobiology of Disease
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
Nicolás W. Martínez, Felipe Gómez, Ariel Tapia-Godoy, Juan Francisco Roa, Fernanda Moreso-Contreras, Yuwei Liu, Claudia Jara, Cheril Tapia-Rojas, Iván Alfaro, Mauro Costa-Mattioli, Soledad Matus
PLOS One
Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology
Vegas-Gomez L, Pizarro M, Garcia-Martin J, Arredondo-Alcala MA, Bustamante B, Gonzalez-Silva C, et al.
Journal of autoimmunity
Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease
Isabel Castro, Patricia Carvajal, Sergio Aguilera, María-José Barrera, Soledad Matus, Sergio González, Claudio Molina, María-Julieta González