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Soledad Matus

Principal Investigator

Biology of Neurodegeneration Lab

smatus@cienciavida.org

Dr. Matus is a biochemist and earned her PhD degree in 2007 at the Faculty of Medicine, Pontificia Universidad Católica de Chile, in Santiago, Chile.

During her PhD studies conducted at the laboratory of Dr. Alfonso González, she worked on a biomedical project in the field of neurobiology aiming to understand the connection between autoimmunity and neurological disorders in the context of human pathology.

She performed postdoctoral training (2008-2011) in protein misfolding and amyotrophic lateral sclerosis (ALS) at the laboratory of Dr. Claudio Hetz at Universidad de Chile supported by a fellowship from the ALS Association (USA). Dr. Matus then started her own laboratory at Neurounion Biomedical Foundation. In 2017 she began her work as principal investigator of the Laboratory of Biology of Neurodegeneration at Fundación Ciencia & Vida.

Collaborations

Mauro Costa Mattioli, Altos Labs, Bay Area Institute of Science, CA, USA. Sandrine Da Cruz, Leuven Brain Institute, KU Leuven, Belgium. Eugenia Morselli, Universidad San Sebastián. Margarita Calvo, Pontificia Universidad Católica.

Grants

FONDECYT R-1230334 [2025-2027] UNRAVELLING THE ROLE OF THE STRESS SENSOR GCN2 AS NEW THERAPEUTIC TARGET IN AMYOTROPHIC LATERAL SCLEROSIS. (Principal Investigator)

Featured Publications presents a curated selection of the researcher’s most significant scientific contributions, reflecting their expertise, findings, and the broader impact of their work in advancing knowledge within their field.

Selected Publications

Neurobiology of Disease
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

https://doi.org/10.1016/j.nbd.2025.107113

PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
PLOS One
Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology

https://doi.org/10.1371/journal.pone.0328470

Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology
Journal of autoimmunity
Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease

https://doi.org/10.1016/j.jaut.2025.103412

Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease

Neurobiology of Disease

PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

https://doi.org/10.1016/j.nbd.2025.107113

PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

Nicolás W. Martínez, Felipe Gómez, Ariel Tapia-Godoy, Juan Francisco Roa, Fernanda Moreso-Contreras, Yuwei Liu, Claudia Jara, Cheril Tapia-Rojas, Iván Alfaro, Mauro Costa-Mattioli, Soledad Matus

PLOS One

Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology

https://doi.org/10.1371/journal.pone.0328470

Vegas-Gomez L, Pizarro M, Garcia-Martin J, Arredondo-Alcala MA, Bustamante B, Gonzalez-Silva C, et al.

Journal of autoimmunity

Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease

https://doi.org/10.1016/j.jaut.2025.103412

Isabel Castro, Patricia Carvajal, Sergio Aguilera, María-José Barrera, Soledad Matus, Sergio González, Claudio Molina, María-Julieta González

Neurobiology of Disease

PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
https://doi.org/10.1016/j.nbd.2025.107113
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
Nicolás W. Martínez, Felipe Gómez, Ariel Tapia-Godoy, Juan Francisco Roa, Fernanda Moreso-Contreras, Yuwei Liu, Claudia Jara, Cheril Tapia-Rojas, Iván Alfaro, Mauro Costa-Mattioli, Soledad Matus

PLOS One

Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology
https://doi.org/10.1371/journal.pone.0328470
Vegas-Gomez L, Pizarro M, Garcia-Martin J, Arredondo-Alcala MA, Bustamante B, Gonzalez-Silva C, et al.

Journal of autoimmunity

Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease
https://doi.org/10.1016/j.jaut.2025.103412
Isabel Castro, Patricia Carvajal, Sergio Aguilera, María-José Barrera, Soledad Matus, Sergio González, Claudio Molina, María-Julieta González
Neurobiology of Disease
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner
PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

https://doi.org/10.1016/j.nbd.2025.107113

PLOS One
Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology
Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology

https://doi.org/10.1371/journal.pone.0328470

Journal of autoimmunity
Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease
Integrated stress response inhibition restores hsa-miR-145-5p levels after IFN-β stimulation in salivary gland epithelial cells. Association between cellular stress and miRNA biogenesis in Sjögren's disease

https://doi.org/10.1016/j.jaut.2025.103412

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