Preclinical Pharmacology Laboratory

Maintaining genetic integrity in mouse colonies is essential for reproducible results. We provide expert guidance on strain selection, colony design, and quality control—advising on strain-specific characteristics and building tailored breeding strategies that protect study validity and timelines.

We commonly assist with:

• Designing efficient breeding programs when establishing colonies from vendor founders.

• Planning crosses to generate compound (double/triple) transgenic lines.

• Verifying and maintaining the intended genetic background(s).

• Choosing between congenic vs. non-congenic strategies and defining backcross plans.

• Selecting appropriate control cohorts for specific experimental designs.

• Preventing genetic drift and substrain divergence through planned breeding and periodic QC.

Our vivarium houses mice, rats, and rabbits in individually ventilated cages (IVCs), static micro-isolator cages, and open-top cages as appropriate. Enclosures are sanitized on a defined schedule—and ad hoc when needed—to maintain optimal hygiene. Animals receive purified, filtered water and species-specific diets, and they benefit from environmental enrichment that supports natural behaviors and welfare.

All cages are inspected daily to detect health issues early and to replenish food and water. When concerns arise, veterinary staff assess the animals, advise investigators, and implement solutions. Treatments and specialized husbandry can be provided upon request.

• Use of drugs (e.g., antibiotics, anesthetics, tranquilizers, and analgesics) for specific research purposes

• Treatment of sick animals

• Surgical procedures and training

• Developing experimental protocols

• Determination of endpoint on animals in moribund state

• Preventive medicine

• Pain management

• Handling

• Blood Sampling

• Administration of Substances

• Anesthesia

• Survival Surgery

• Necropsy