1. Inflammation, Autoimmunity and Immune Intervention
Aims to elucidate key mechanisms of immune regulation across tissues in health and disease to identify biomarkers and targeted immunotherapies for inflammatory and autoimmune disorders.
Research
Research excellence in the biological sciences
More than 300 investigators work at the Center in biomedicine, microbiology and computational biology, organized in five research clusters that collaborate with one another.
Research clusters
We seek to generate knowledge that leads to innovations addressing relevant social and economic challenges: inflammatory and autoimmune diseases, viral infections, cancer, neurodegeneration and fibrosis, microbial biotechnology, sustainable mining and data-driven health forecasting.
2. Viruses, Microbes and Biotechnology
Aims to uncover the principles of viral pathogenesis, microbial adaptation, and biodiversity to advance solutions in infectious disease, sustainable mining, and microbe-based biotechnology.
3. Gene Regulation and Translational Cancer Research
Aims to define the molecular and cellular networks driving cancer progression and treatment response to develop biomarkers and next-generation therapies
4. Neurodegeneration, Tissue Repair and Therapies
Aims to identify the stress, neuroimmune, and fibrotic mechanisms underlying neurodegeneration and tissue damage to support the development of innovative therapeutic strategies.
5. Modeling and Computational Biology
Aims to build predictive computational frameworks linking molecular, cellular, and population-level data to accelerate biological discovery, as well as health nowcasting and forecasting.
Laboratories
Each laboratory is led by a principal investigator and works independently, in dialogue with the other research clusters and with access to shared platforms for microscopy, flow cytometry, animal facilities and computing.
María Rosa Bono
Senior InvestigatorUniversidad de Chile Immunology Laboratory
Alfonso González de la Rosa
Senior InvestigatorBiomedical Cytology Laboratory
Mario Rosemblatt Silber
Senior InvestigatorCellular and Molecular Immunology Laboratory
Tomás Pérez-Acle
Principal InvestigatorBioinspired Artificial Intelligence Laboratory
Enrique Brandan Siques
Principal InvestigatorCell Differentiation and Pathology Laboratory
Alvaro Lladser Caldera
Principal InvestigatorImmunoncology Laboratory
Alejandra Loyola Pedevila
Principal InvestigatorEpigenetics and Chromatin Laboratory
Rodrigo Pacheco Rivera
Principal InvestigatorNeuroimmunology Laboratory
Raquel Quatrini Nyqvist
Principal InvestigatorMicrobial Ecophysiology Laboratory
Cheril Tapia Rojas
Principal InvestigatorNeurobiology of Aging Laboratory
Nicole Tischler
Principal InvestigatorMolecular Virology Laboratory
Alberto Martin Martin
Principal InvestigatorNetwork Biology Laboratory
Manuel Varas Godoy
Principal InvestigatorCancer Cell Biology Laboratory
Fabiola Osorio Olivares
Principal InvestigatorImmunology Laboratory
Francisco Cubillos Riffo
Principal InvestigatorMolecular Genetics LaboratoryPublications
A selection of recent publications from our five research clusters, many of them written with collaborators in Chile and abroad.
Oct 1, 2026Climate-driven adaptive microevolution in wild yeastsProceedings of the National Academy of SciencesNo documented research clusterJul 9, 2026A symmetric region produces a novel calcium binding mode in the human Cx46 connexonProtein ScienceResearch cluster V · Modeling and Computational BiologyJul 7, 2026The Orthohantavirus GN/GC Spikes: Molecular Determinants of Infection and Targets for Antiviral Immune InterventionsAnnual Review of VirologyResearch cluster II · Viruses, Microbes and BiotechnologyApr 3, 2026Senescent Schwann cells as therapeutic targets in nerve regeneration and peripheral neuropathiesTrends in Molecular MedicineResearch cluster IV · Neurodegeneration, Tissue Repair and TherapiesMar 19, 2026Integrative omics and phase IIa clinical trial identify TNF as key node in autoimmune hepatitisJournal of HepatologyResearch cluster I · Inflammation, Autoimmunity and Immune InterventionMar 13, 2026Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunityOncoImmunologyResearch cluster III · Gene Regulation and Translational Cancer Research
