Immunology Laboratory

Chronic inflammatory diseases can develop silently over many years before becoming clinically apparent. Long before overt tissue damage occurs, cells face environmental changes that disrupt protein homeostasis and activate stress responses, such as the Unfolded Protein Response (UPR). Although initially protective, these responses can contribute to inflammation when dysregulated or persistently activated.

Our laboratory investigates how innate immune cells, particularly macrophages and dendritic cells, sense and integrate cellular stress signals, and how these signals shape immune function and tissue homeostasis. Using a variety of experimental models, including animal and human systems, we aim to uncover the molecular mechanisms linking proteostasis to inflammation and tissue damage, identifying new opportunities to intervene in these processes.